CCNF
Gene Ontology Biological Process
Gene Ontology Molecular Function
CAD
Gene Ontology Biological Process
- 'de novo' pyrimidine nucleobase biosynthetic process [IDA, ISS]
- arginine biosynthetic process [IBA]
- drug metabolic process [ISS]
- glutamine metabolic process [ISS]
- nucleobase-containing small molecule metabolic process [TAS]
- peptidyl-threonine phosphorylation [ISS]
- protein autophosphorylation [ISS]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside biosynthetic process [TAS]
- small molecule metabolic process [TAS]
- urea cycle [IBA]
Gene Ontology Molecular Function- ATP binding [ISS]
- aspartate binding [ISS]
- aspartate carbamoyltransferase activity [IBA, ISS, TAS]
- carbamoyl-phosphate synthase (ammonia) activity [IBA]
- carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [IBA, ISS, TAS]
- dihydroorotase activity [IDA, ISS, TAS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein kinase activity [ISS]
- zinc ion binding [IDA]
- ATP binding [ISS]
- aspartate binding [ISS]
- aspartate carbamoyltransferase activity [IBA, ISS, TAS]
- carbamoyl-phosphate synthase (ammonia) activity [IBA]
- carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [IBA, ISS, TAS]
- dihydroorotase activity [IDA, ISS, TAS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein kinase activity [ISS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CCNF CAD | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 2.213 | BioGRID | 3305265 | |
| CCNF CAD | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID