BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
AIFM1
AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, RP3-438D16.2
apoptosis-inducing factor, mitochondrion-associated, 1
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA catabolic process [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [IMP]
- chromosome condensation [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- mitochondrial respiratory chain complex I assembly [IMP]
- neuron differentiation [IDA]
- positive regulation of apoptotic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID