BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CDK5
PSSALRE
cyclin-dependent kinase 5
GO Process (25)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- axon extension [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- negative regulation of neuron death [IDA]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neuron apoptotic process [TAS]
- neuron differentiation [ISS, TAS]
- neuron migration [TAS]
- neuron projection development [ISS]
- oligodendrocyte differentiation [IDA]
- peptidyl-serine phosphorylation [IDA]
- phosphorylation [IDA]
- positive regulation of actin cytoskeleton reorganization [TAS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of apoptotic process [TAS]
- regulation of cell cycle arrest [TAS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of synaptic plasticity [ISS, TAS]
- regulation of synaptic vesicle recycling [NAS]
- synapse assembly [TAS]
- synaptic transmission [TAS]
- synaptic vesicle endocytosis [TAS]
- synaptic vesicle exocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID