BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
NDUFA13
B16.6, CDA016, GRIM-19, GRIM19, CGI-39
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
GO Process (14)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- apoptotic signaling pathway [IDA]
- cellular metabolic process [TAS]
- cellular response to interferon-beta [IDA]
- cellular response to retinoic acid [IDA]
- negative regulation of cell growth [IDA, IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IGI]
- positive regulation of peptidase activity [IC]
- positive regulation of protein catabolic process [IGI]
- protein import into mitochondrial inner membrane [IDA]
- reactive oxygen species metabolic process [IMP]
- respiratory electron transport chain [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID