BAIT

CCNF

FBX1, FBXO1
cyclin F
UPS Project
GO Process (3)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

RRBP1

1700087N07Rik, 5730465C04Rik, ES/130, mKIAA1398, mRRp0, mRRp1.8, mRRp10, mRRp15a, mRRp15b, mRRp16.8, mRRp2, mRRp41, mRRp47, mRRp5.4, p180, RP23-77A2.2
ribosome binding protein 1
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Mus musculus

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

ALS-linked loss of Cyclin-F function affects HSP90.

Siebert A, Gattringer V, Weishaupt JH, Behrends C

The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]

Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]

Throughput

  • High Throughput

Curated By

  • BioGRID