BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
EIF2B2
AA409345, C85417, EIF-2Bbeta, EIF2B
eukaryotic translation initiation factor 2B, subunit 2 beta
GO Process (11)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cellular response to stimulus [ISO]
- central nervous system development [ISO]
- myelination [ISO]
- oligodendrocyte development [ISO]
- ovarian follicle development [ISO]
- positive regulation of GTPase activity [IBA, ISO]
- regulation of translational initiation [IBA]
- response to glucose [ISO]
- response to heat [ISO]
- response to peptide hormone [ISO]
- translational initiation [ISO]
Gene Ontology Molecular Function
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID