BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ARHGEF2
AA408978, GEF, GEF-H1, GEFH1, LFP40, Lbcl1, Lfc, P40, mKIAA0651
rho/rac guanine nucleotide exchange factor (GEF) 2
GO Process (14)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- actin filament organization [IPI, ISO]
- cell morphogenesis [IDA, ISO]
- cellular response to muramyl dipeptide [ISO]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of microtubule depolymerization [ISO]
- negative regulation of neurogenesis [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Rho GTPase activity [IDA, ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- regulation of Rho protein signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID