BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
GOT2
AL022787, FABP-pm, Got-2, mAspAT
glutamatic-oxaloacetic transaminase 2, mitochondrial
GO Process (9)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- aspartate biosynthetic process [IDA]
- aspartate catabolic process [ISO]
- aspartate metabolic process [ISO]
- cellular amino acid metabolic process [ISO]
- dicarboxylic acid metabolic process [ISO]
- glutamate catabolic process to 2-oxoglutarate [IDA]
- glutamate catabolic process to aspartate [IDA]
- oxaloacetate metabolic process [IDA]
- response to ethanol [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID