BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CALR
CRT, Calregulin
calreticulin
GO Process (22)
GO Function (13)
GO Component (21)
Gene Ontology Biological Process
- cell cycle arrest [ISO]
- cellular senescence [IMP, ISO]
- chaperone-mediated protein folding [ISO]
- cortical actin cytoskeleton organization [IDA]
- negative regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of retinoic acid receptor signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of translation [ISO]
- peptide antigen assembly with MHC class I protein complex [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of cell cycle [IMP, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of dendritic cell chemotaxis [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein export from nucleus [ISO]
- protein localization to nucleus [IMP, ISO]
- protein stabilization [IDA]
- regulation of meiosis [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MHC class I peptide loading complex [IMP]
- acrosomal vesicle [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO, ISS]
- endoplasmic reticulum lumen [IDA, ISO]
- external side of plasma membrane [IDA]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- polysome [IDA]
- protein complex [ISO]
- sarcoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID