BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
FKBP4
59kDa, AL022792, AW208983, FKBP-4, FKBP-52, FKBP52, FKPB52, p59
FK506 binding protein 4
GO Process (11)
GO Function (11)
GO Component (11)
Gene Ontology Biological Process
- androgen receptor signaling pathway [IMP]
- chaperone-mediated protein folding [IBA, ISO]
- copper ion transport [ISO]
- embryo implantation [IMP]
- male sex differentiation [IMP]
- negative regulation of microtubule polymerization [ISO]
- prostate gland development [IMP]
- protein complex localization [IDA]
- protein peptidyl-prolyl isomerization [IBA, ISO]
- reproductive structure development [IMP]
- steroid hormone receptor complex assembly [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- FK506 binding [IBA]
- GTP binding [IDA]
- copper-dependent protein binding [ISO]
- glucocorticoid receptor binding [IDA]
- heat shock protein binding [IDA, ISO]
- peptidyl-prolyl cis-trans isomerase activity [IBA, ISO]
- phosphoprotein binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
- ATP binding [IDA]
- FK506 binding [IBA]
- GTP binding [IDA]
- copper-dependent protein binding [ISO]
- glucocorticoid receptor binding [IDA]
- heat shock protein binding [IDA, ISO]
- peptidyl-prolyl cis-trans isomerase activity [IBA, ISO]
- phosphoprotein binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID