BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CANX
1110069N15Rik, AI988026, Cnx, D11Ertd153e, RP23-237P10.2
calnexin
GO Process (3)
GO Function (6)
GO Component (16)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER-mitochondrion membrane contact site [ISO]
- axon [ISO]
- cell [IMP]
- cytoplasm [ISO]
- dendrite cytoplasm [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- integral component of membrane [IDA]
- membrane [IDA, ISO]
- myelin sheath [IDA]
- neuronal cell body [ISO]
- protein complex [ISO]
- ribosome [ISO]
- rough endoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID