BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
POR
4933424M13Rik, CPR, CYPOR
P450 (cytochrome) oxidoreductase
GO Process (17)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cellular organofluorine metabolic process [ISO]
- demethylation [ISO]
- fatty acid oxidation [ISO]
- internal peptidyl-lysine acetylation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of lipase activity [ISO]
- nitrate catabolic process [ISO]
- nitric oxide catabolic process [ISO]
- oxidation-reduction process [IMP, ISO]
- positive regulation of cholesterol biosynthetic process [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of monooxygenase activity [ISO]
- positive regulation of smoothened signaling pathway [ISO]
- positive regulation of steroid hormone biosynthetic process [ISO]
- regulation of cholesterol metabolic process [ISO]
- regulation of growth plate cartilage chondrocyte proliferation [ISO]
Gene Ontology Molecular Function- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA, ISO]
- cytochrome-b5 reductase activity, acting on NAD(P)H [ISO]
- electron carrier activity [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- hydrolase activity [ISO]
- iron-cytochrome-c reductase activity [ISO]
- nitric oxide dioxygenase activity [ISO]
- oxidoreductase activity [IMP]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA, ISO]
- cytochrome-b5 reductase activity, acting on NAD(P)H [ISO]
- electron carrier activity [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- hydrolase activity [ISO]
- iron-cytochrome-c reductase activity [ISO]
- nitric oxide dioxygenase activity [ISO]
- oxidoreductase activity [IMP]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID