BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PFKM
AI131669, ATP-PFK, PFK-A, PFK-M, Pfk-4, Pfk4, Pfka, Pfkx
phosphofructokinase, muscle
GO Process (10)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- carbohydrate phosphorylation [IMP, ISO]
- fructose 1,6-bisphosphate metabolic process [ISO]
- fructose 6-phosphate metabolic process [ISO]
- glucose homeostasis [IMP]
- glycolytic process [IDA, IMP, ISO, ISS]
- glycolytic process through fructose-6-phosphate [IC]
- muscle cell cellular homeostasis [ISO]
- positive regulation of insulin secretion [IMP]
- protein homotetramerization [ISO]
- protein oligomerization [ISO]
Gene Ontology Molecular Function- 6-phosphofructokinase activity [IDA, IMP, ISO, ISS]
- AMP binding [ISO]
- ATP binding [ISO]
- carbohydrate binding [ISO]
- fructose binding [ISO]
- fructose-6-phosphate binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- phosphofructokinase activity [IDA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- 6-phosphofructokinase activity [IDA, IMP, ISO, ISS]
- AMP binding [ISO]
- ATP binding [ISO]
- carbohydrate binding [ISO]
- fructose binding [ISO]
- fructose-6-phosphate binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- phosphofructokinase activity [IDA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID