BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SLC25A4
AU019225, Ant1
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
GO Process (9)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- apoptotic mitochondrial changes [IGI]
- ion transmembrane transport [ISO]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of mitochondrial membrane permeability involved in apoptotic process [ISO]
- negative regulation of necroptotic process [ISO]
- nucleotide transmembrane transport [ISO]
- positive regulation of cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of oxidative phosphorylation uncoupler activity [ISO]
- purine nucleoside transmembrane transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID