BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
HSD17B4
17-beta-HSD, 17[b]-HSD, 4, DBP, MFE-2, MFP2, MPF-2, Mfp-2, perMFE-2
hydroxysteroid (17-beta) dehydrogenase 4
GO Process (10)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- Sertoli cell development [IMP]
- androgen metabolic process [ISO]
- estrogen metabolic process [ISO]
- fatty acid beta-oxidation [IMP, ISO]
- medium-chain fatty-acyl-CoA metabolic process [ISO]
- metabolic process [ISO]
- osteoblast differentiation [ISO]
- oxidation-reduction process [ISO]
- very long-chain fatty acid metabolic process [IMP]
- very long-chain fatty-acyl-CoA metabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID