BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PEBP1
HCNP, Pbp, Pbp1, Pbpr, Rkip
phosphatidylethanolamine binding protein 1
GO Process (9)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of protein phosphorylation [ISO]
- positive regulation of acetylcholine metabolic process [ISO]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of mitosis [ISO]
- regulation of neurotransmitter levels [ISO]
- regulation of the force of heart contraction [ISO]
- sperm capacitation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- apical part of cell [ISO]
- axon terminus [ISO]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- mitochondrial outer membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- rough endoplasmic reticulum [ISO]
- synaptic vesicle [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID