BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
JUP
Ctnng, D930025P04Rik, PG, RP23-392I3.6
junction plakoglobin
GO Process (17)
GO Function (7)
GO Component (21)
Gene Ontology Biological Process
- bundle of His cell to Purkinje myocyte communication [ISO]
- cell adhesion [IDA]
- cell migration [ISO]
- cellular response to indole-3-methanol [ISO]
- desmosome assembly [IMP, ISO]
- detection of mechanical stimulus [ISO]
- establishment of protein localization to plasma membrane [ISO]
- positive regulation of protein import into nucleus [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein heterooligomerization [ISO]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of nucleic acid-templated transcription [IBA]
- single organismal cell-cell adhesion [IMP, ISO]
- skin development [IMP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- actin cytoskeleton [ISO]
- apicolateral plasma membrane [ISO]
- catenin complex [IBA, ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- cytosol [IDA]
- desmosome [IDA, IMP, ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [ISO]
- focal adhesion [ISO]
- gamma-catenin-TCF7L2 complex [ISO]
- intercalated disc [ISO]
- intermediate filament [IDA]
- lateral plasma membrane [ISO]
- membrane [IDA]
- nucleus [IBA, ISO]
- plasma membrane [ISO]
- protein-DNA complex [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID