BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ACACA
A530025K05Rik, Acac, Acc1, Gm738, RP23-123O10.1
acetyl-Coenzyme A carboxylase alpha
GO Process (9)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- acetyl-CoA metabolic process [IDA, ISO]
- cellular response to prostaglandin E stimulus [IDA]
- fatty acid biosynthetic process [IDA, ISO]
- lipid homeostasis [IMP]
- lipid metabolic process [IMP]
- multicellular organismal protein metabolic process [IMP]
- protein homotetramerization [IDA]
- response to organic cyclic compound [ISO]
- tissue homeostasis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID