BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
RAB14
0610030G24Rik, 2810475J17Rik, A830021G03Rik, AI314285, AI649155, D030017L14Rik, RP23-186B18.6
RAB14, member RAS oncogene family
GO Process (11)
GO Function (6)
GO Component (22)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi to endosome transport [IMP]
- Rab protein signal transduction [IBA]
- apical protein localization [ISO]
- body fluid secretion [ISO]
- embryo development [IMP]
- endocytic recycling [ISO]
- fibroblast growth factor receptor signaling pathway [IMP]
- intracellular protein transport [IBA]
- phagolysosome assembly involved in apoptotic cell clearance [IBA]
- regulation of protein localization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IBA]
- Golgi stack [ISO]
- alveolar lamellar body [ISO]
- apical plasma membrane [ISO]
- cell [IMP]
- cytoplasm [IMP]
- cytosol [ISO]
- early endosome [IBA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP, ISO]
- intracellular membrane-bounded organelle [ISO]
- late endosome [ISO]
- lysosomal membrane [ISO]
- lysosome [ISO]
- nuclear outer membrane-endoplasmic reticulum membrane network [ISO]
- perinuclear region of cytoplasm [ISO]
- phagocytic vesicle [IBA, ISO]
- plasma membrane [ISO]
- recycling endosome [ISO]
- rough endoplasmic reticulum [ISO]
- trans-Golgi network transport vesicle [ISO]
- transport vesicle [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID