BAIT

CCNF

FBX1, FBXO1

cyclin F

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]

negative regulation of centrosome duplication [IDA]

protein ubiquitination [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

SCF ubiquitin ligase complex [IDA]

centriole [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PARK7

DJ-1, Dj1, RP23-272N19.5

Parkinson disease (autosomal recessive, early onset) 7

GO Process (19)

GO Function (2)

GO Component (5)

Gene Ontology Biological Process

adult locomotory behavior [IMP]

cell proliferation [TAS]

cellular response to hydrogen peroxide [IMP]

cellular response to oxidative stress [IMP]

cellular response to reactive oxygen species [IMP]

dopamine uptake involved in synaptic transmission [IMP]

hydrogen peroxide metabolic process [IMP]

membrane depolarization [IMP]

membrane hyperpolarization [IMP]

mitochondrion organization [IMP]

negative regulation of cell death [IMP]

oxidation-reduction process [IMP]

positive regulation of oxidative phosphorylation uncoupler activity [IMP]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]

positive regulation of reactive oxygen species biosynthetic process [IDA]

protein stabilization [IMP]

regulation of inflammatory response [IMP]

response to hydrogen peroxide [IDA, IMP]

synaptic transmission, dopaminergic [IMP]

Gene Ontology Molecular Function

RNA binding [TAS]
peroxiredoxin activity [IMP]

Gene Ontology Cellular Component

cytoplasm [ISO]

endoplasmic reticulum [IDA]

mitochondrion [IDA]

nucleus [IDA, ISO]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

ALS-linked loss of Cyclin-F function affects HSP90.

Siebert A, Gattringer V, Weishaupt JH, Behrends C

The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]

Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CCNF PARK7	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Siebert A (2022)	High	-	BioGRID	-

Curated By

BioGRID