BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
STK39
AW227544, AW556857, DCHT, RF005, Rnl5, SPAK, RP23-27J1.4
serine/threonine kinase 39
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- intracellular signal transduction [IBA, ISO]
- negative regulation of potassium ion transmembrane transport [IDA, ISO]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of rubidium ion transmembrane transporter activity [ISO]
- negative regulation of rubidium ion transport [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of potassium ion transport [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of blood pressure [IMP]
- regulation of inflammatory response [IDA]
- regulation of ion homeostasis [IMP]
- signal transduction by phosphorylation [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID