BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
WASL
N-WASP, NWASP
Wiskott-Aldrich syndrome-like
GO Process (15)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- actin polymerization or depolymerization [TAS]
- axon guidance [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- membrane budding [ISS]
- negative regulation of membrane tubulation [IDA]
- nitric oxide metabolic process [TAS]
- positive regulation of clathrin-mediated endocytosis [ISS]
- positive regulation of filopodium assembly [ISS]
- protein complex assembly [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- small molecule metabolic process [TAS]
- vesicle organization [ISS]
- vesicle transport along actin filament [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID