BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
OGT
HRNT1, O-GLCNAC
O-linked N-acetylglucosamine (GlcNAc) transferase
GO Process (24)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [IDA]
- cellular response to retinoic acid [IMP]
- chromatin organization [TAS]
- circadian regulation of gene expression [ISS]
- histone H3-K4 trimethylation [IMP]
- histone H4-K16 acetylation [IDA]
- histone H4-K5 acetylation [IDA]
- histone H4-K8 acetylation [IDA]
- negative regulation of protein ubiquitination [ISS]
- phosphatidylinositol-mediated signaling [IDA]
- positive regulation of catalytic activity [IDA]
- positive regulation of granulocyte differentiation [IMP]
- positive regulation of histone H3-K27 methylation [IMP]
- positive regulation of histone H3-K4 methylation [IDA]
- positive regulation of proteolysis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- protein O-linked glycosylation [IDA, IMP]
- regulation of Rac protein signal transduction [IDA]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [ISS]
- regulation of glycolytic process [IDA]
- regulation of insulin receptor signaling pathway [IDA]
- response to insulin [IDA]
- response to nutrient [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function- acetylglucosaminyltransferase activity [TAS]
- enzyme activator activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- protein N-acetylglucosaminyltransferase activity [IDA]
- protein O-GlcNAc transferase activity [IMP, ISS]
- protein binding [IPI]
- acetylglucosaminyltransferase activity [TAS]
- enzyme activator activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- protein N-acetylglucosaminyltransferase activity [IDA]
- protein O-GlcNAc transferase activity [IMP, ISS]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID