BAIT

CCNF

FBX1, FBXO1

cyclin F

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]

negative regulation of centrosome duplication [IDA]

protein ubiquitination [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

SCF ubiquitin ligase complex [IDA]

centriole [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

PTPN1

PTP1B

protein tyrosine phosphatase, non-receptor type 1

Alzheimer's Disease Project

GO Process (19)

GO Function (8)

GO Component (5)

Gene Ontology Biological Process

JAK-STAT cascade involved in growth hormone signaling pathway [TAS]

actin cytoskeleton reorganization [IMP]

blood coagulation [TAS]

cytokine-mediated signaling pathway [TAS]

endoplasmic reticulum unfolded protein response [IDA]

interferon-gamma-mediated signaling pathway [TAS]

negative regulation of ERK1 and ERK2 cascade [ISS]

negative regulation of insulin receptor signaling pathway [NAS]

negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS]

peptidyl-tyrosine dephosphorylation [IDA, IMP]

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [ISS]

platelet activation [TAS]

platelet-derived growth factor receptor-beta signaling pathway [IMP]

regulation of endocytosis [IDA]

regulation of hepatocyte growth factor receptor signaling pathway [IMP]

regulation of interferon-gamma-mediated signaling pathway [TAS]

regulation of signal transduction [IMP]

regulation of type I interferon-mediated signaling pathway [TAS]

type I interferon signaling pathway [TAS]

Gene Ontology Molecular Function

enzyme binding [IPI]
ephrin receptor binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
protein tyrosine phosphatase activity [IDA, TAS]
receptor tyrosine kinase binding [IPI]
zinc ion binding [IDA]

Gene Ontology Cellular Component

early endosome [IDA]

endoplasmic reticulum [IDA]

plasma membrane [IDA]

sorting endosome [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

ALS-linked loss of Cyclin-F function affects HSP90.

Siebert A, Gattringer V, Weishaupt JH, Behrends C

The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]

Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CCNF PTPN1	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Siebert A (2022)	High	-	BioGRID	-

Curated By

BioGRID