BAIT

TRIM50

tripartite motif-containing 50
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

NLRP3

AGTAVPRL, AII/AVP, Cias1, FCAS, FCU, MWS, Mmig1, NALP3, Pypaf1, RP23-210M6.4
NLR family, pyrin domain containing 3
Mus musculus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.

Lin Y, Lv X, Sun C, Sun Y, Yang M, Ma D, Jing W, Zhao Y, Cheng Y, Xuan H, Han L

Tripartite motif protein (TRIM) 50 is a new member of the tripartite motif family, and its biological function and the molecular mechanism it is involved in remain largely unknown. The NOD-like receptor family protein (NLRP)3 inflammasome is actively involved in a wide array of biological processes while mechanisms of its regulation remain to be fully clarified. Here, we demonstrate the ... [more]

EMBO Rep Nov. 07, 2022; 23(11);e54569 [Pubmed: 36178239]

Throughput

  • Low Throughput

Curated By

  • BioGRID