BAIT
STIP1
HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
stress-induced phosphoprotein 1
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ZW10
HZW10, KNTC1AP
zw10 kinetochore protein
GO Process (11)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IMP]
- Golgi organization [IGI, IMP]
- establishment of mitotic spindle orientation [IMP]
- meiotic nuclear division [TAS]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [IDA]
- mitotic metaphase plate congression [IMP]
- mitotic sister chromatid segregation [IDA]
- protein complex assembly [IDA]
- protein localization to kinetochore [IMP]
- regulation of exit from mitosis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.
Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of eukaryotes and bacteria lack an ortholog. We set out to identify and to characterize its eukaryote-specific function. Human cell lines and the ... [more]
Nat Commun Nov. 25, 2020; 11(1);5975 [Pubmed: 33239621]
Throughput
- High Throughput
Curated By
- BioGRID