BAIT
STIP1
HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
stress-induced phosphoprotein 1
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRPF19
NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4
pre-mRNA processing factor 19
GO Process (10)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- cellular protein localization [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- generation of catalytic spliceosome for first transesterification step [IBA]
- mRNA splicing, via spliceosome [IC, IDA]
- proteasomal protein catabolic process [IMP]
- protein K63-linked ubiquitination [IMP]
- protein polyubiquitination [IDA]
- signal transduction involved in DNA damage checkpoint [IMP]
- spliceosomal complex assembly [IMP]
- spliceosomal tri-snRNP complex assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.
Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of eukaryotes and bacteria lack an ortholog. We set out to identify and to characterize its eukaryote-specific function. Human cell lines and the ... [more]
Nat Commun Nov. 25, 2020; 11(1);5975 [Pubmed: 33239621]
Throughput
- High Throughput
Curated By
- BioGRID