BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
ITGAV
1110004F14Rik, 2610028E01Rik, CD51, D430040G12Rik, RP23-111F12.3
integrin alpha V
GO Process (45)
GO Function (11)
GO Component (18)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- T cell activation [TAS]
- apolipoprotein A-I-mediated signaling pathway [ISO]
- apoptotic cell clearance [IMP]
- blood vessel development [IMP]
- calcium ion transmembrane transport [ISO]
- cell adhesion [ISO]
- cell growth [ISO]
- cell migration [ISO]
- cell-matrix adhesion [ISO, TAS]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [ISO]
- detection of molecule of bacterial origin [TAS]
- endodermal cell differentiation [ISO]
- endothelial cell migration [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- fertilization [NAS]
- focal adhesion assembly [NAS]
- gonad morphogenesis [NAS]
- heterotypic cell-cell adhesion [ISO]
- inflammatory response [TAS]
- integrin-mediated signaling pathway [ISO]
- negative chemotaxis [ISO]
- negative regulation of entry of bacterium into host cell [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of lipid storage [ISO]
- negative regulation of lipid transport [ISO]
- negative regulation of lipoprotein metabolic process [ISO]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of osteoblast proliferation [IMP]
- regulation of apoptotic cell clearance [IDA]
- regulation of bone resorption [TAS]
- regulation of ion transmembrane transport [ISO]
- regulation of phagocytosis [ISO, NAS]
- release of sequestered calcium ion into cytosol [TAS]
- response to nitric oxide [TAS]
- substrate adhesion-dependent cell spreading [ISO]
- trophoblast giant cell differentiation [TAS]
- viral entry into host cell [ISO]
Gene Ontology Molecular Function- extracellular matrix binding [ISO]
- extracellular matrix protein binding [ISO]
- fibronectin binding [ISO]
- insulin-like growth factor I binding [ISO]
- opsonin binding [IDA]
- peptide binding [ISO]
- protease binding [ISO]
- protein heterodimerization activity [TAS]
- protein kinase C binding [IDA]
- receptor binding [ISO]
- voltage-gated calcium channel activity [ISO]
- extracellular matrix binding [ISO]
- extracellular matrix protein binding [ISO]
- fibronectin binding [ISO]
- insulin-like growth factor I binding [ISO]
- opsonin binding [IDA]
- peptide binding [ISO]
- protease binding [ISO]
- protein heterodimerization activity [TAS]
- protein kinase C binding [IDA]
- receptor binding [ISO]
- voltage-gated calcium channel activity [ISO]
Gene Ontology Cellular Component
- alphav-beta3 integrin-IGF-1-IGF1R complex [ISO]
- cell surface [ISO]
- cytosol [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- integrin alphav-beta3 complex [ISO, TAS]
- integrin alphav-beta5 complex [ISO]
- integrin alphav-beta8 complex [ISO]
- integrin complex [ISO]
- intracellular [IDA]
- lamellipodium membrane [ISO]
- membrane [IDA]
- microvillus membrane [ISO]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
- ruffle membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID