BAIT
PCDH7
BH-Pcdh, BHPCDH, PPP1R120
protocadherin 7
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
PREY
ACSL3
ACS3, FACL3, PRO2194
acyl-CoA synthetase long-chain family member 3
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- long-chain fatty acid import [IDA]
- long-chain fatty acid metabolic process [IMP]
- positive regulation of Golgi to plasma membrane protein transport [IMP]
- positive regulation of phosphatidylcholine biosynthetic process [IMP]
- positive regulation of secretion [IMP]
- very-low-density lipoprotein particle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis.
Cell division requires dramatic reorganization of the cell cortex, which is primarily driven by the actomyosin network. We previously reported that protocadherin 7 (PCDH7) gets enriched at the cell surface during mitosis, which is required to build up the full mitotic rounding pressure. Here, we report that PCDH7 interacts with and is palmitoylated by the palmitoyltransferase, ZDHHC5. PCDH7 and ZDHHC5 ... [more]
J Cell Sci Mar. 15, 2023; 136(6); [Pubmed: 36762613]
Throughput
- High Throughput
Additional Notes
- BioID
- false discovery rate (FDR) of 0.05
Curated By
- BioGRID