BAIT
SLX4
BTBD12, FANCP, MUS312
SLX4 structure-specific endonuclease subunit
GO Process (7)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA double-strand break processing involved in repair via single-strand annealing [IMP]
- DNA repair [IMP]
- double-strand break repair via homologous recombination [IMP]
- nucleotide-excision repair [IMP]
- positive regulation of catalytic activity [IDA]
- response to intra-S DNA damage checkpoint signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KIF2C
CT139, KNSL6, MCAK, RP11-269F19.1
kinesin family member 2C
GO Process (12)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [IMP]
- metabolic process [IBA, TAS]
- microtubule depolymerization [IDA, IMP]
- microtubule-based movement [IBA, TAS]
- mitotic cell cycle [TAS]
- mitotic metaphase plate congression [IMP]
- mitotic nuclear division [TAS]
- regulation of chromosome segregation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.
The DNA repair scaffold SLX4 has pivotal roles in cellular processes that maintain genome stability, most notably homologous recombination. Germline mutations in SLX4 are associated with Fanconi anemia, a disease characterized by chromosome instability and cancer susceptibility. The role of mammalian SLX4 in homologous recombination depends critically on binding and activating structure-selective endonucleases, namely SLX1, MUS81-EME1, and XPF-ERCC1. Increasing evidence ... [more]
J Proteome Res Apr. 18, 2023; (); [Pubmed: 37071664]
Throughput
- High Throughput
Additional Notes
- BFDR less than or equal to 1% were considered high confidence
- BioID
Curated By
- BioGRID