HMGA2
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA damage response, detection of DNA damage [IDA]
- base-excision repair [IDA]
- chondrocyte differentiation [IDA]
- chondrocyte proliferation [IDA]
- chromatin organization [TAS]
- chromosome breakage [IDA]
- endodermal cell differentiation [IMP]
- epithelial to mesenchymal transition [IMP]
- fat cell differentiation [IMP]
- heterochromatin assembly [IDA]
- histone H2A-S139 phosphorylation [IDA]
- mesenchymal cell differentiation [IMP]
- mesodermal cell differentiation [IMP]
- mesodermal-endodermal cell signaling [IMP]
- mitotic G2 DNA damage checkpoint [IDA]
- multicellular organismal development [TAS]
- negative regulation by host of viral transcription [IDA]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of double-strand break repair via nonhomologous end joining [IDA]
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- oncogene-induced cell senescence [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cellular response to X-ray [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of response to DNA damage stimulus [IDA]
- positive regulation of stem cell proliferation [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of cell cycle process [IDA]
- regulation of cellular response to drug [IDA]
- regulation of stem cell maintenance [IMP, TAS]
- regulation of transcription, DNA-templated [IMP]
- response to virus [IEP]
- senescence-associated heterochromatin focus assembly [IDA]
- stem cell differentiation [IEP]
Gene Ontology Molecular Function- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [IDA, IMP]
- C2H2 zinc finger domain binding [IMP]
- DNA binding [NAS]
- DNA binding, bending [IDA, IMP]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- DNA-dependent protein kinase activity [IDA]
- MH1 domain binding [IDA]
- MH2 domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- cAMP response element binding [IDA]
- core promoter binding [IDA]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [IDA, IMP]
- C2H2 zinc finger domain binding [IMP]
- DNA binding [NAS]
- DNA binding, bending [IDA, IMP]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- DNA-dependent protein kinase activity [IDA]
- MH1 domain binding [IDA]
- MH2 domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- cAMP response element binding [IDA]
- core promoter binding [IDA]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
Gene Ontology Cellular Component
XRCC6
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- DNA ligation [TAS]
- DNA repair [TAS]
- double-strand break repair [TAS]
- double-strand break repair via nonhomologous end joining [IMP, TAS]
- establishment of integrated proviral latency [TAS]
- innate immune response [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- telomere maintenance [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling.
The non-histone chromatin binding protein High Mobility Group AT-hook protein 2 (HMGA2) has important functions in chromatin remodeling, and genome maintenance and protection. Expression of HMGA2 is highest in embryonic stem cells, declines during cell differentiation and cell aging, but it is re-expressed in some cancers, where high HMGA2 expression frequently coincides with a poor prognosis. The nuclear functions of ... [more]
Throughput
- High Throughput
Additional Notes
- SILAC BioID2
- miniTurbo AP/MS
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HMGA2 XRCC6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8378 | BioGRID | 3119823 | |
| HMGA2 XRCC6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| XRCC6 HMGA2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | 3437877 | |
| XRCC6 HMGA2 | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | 869806 | |
| HMGA2 XRCC6 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 869799 |
Curated By
- BioGRID