ACVRL1
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- activin receptor signaling pathway [IDA]
- angiogenesis [IMP]
- artery development [ISS]
- blood circulation [IMP]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [TAS]
- blood vessel maturation [TAS]
- blood vessel remodeling [ISS]
- cellular response to BMP stimulus [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- endothelial tube morphogenesis [IMP]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [IMP]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of blood vessel endothelial cell migration [IMP]
- negative regulation of cell adhesion [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of focal adhesion assembly [IMP]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of chondrocyte differentiation [TAS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of DNA replication [TAS]
- regulation of blood pressure [IMP]
- regulation of blood vessel endothelial cell migration [TAS]
- regulation of endothelial cell proliferation [TAS]
- regulation of transcription, DNA-templated [IMP]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
- venous blood vessel development [ISS]
- wound healing, spreading of epidermal cells [IMP]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
Gene Ontology Cellular Component
EIF4E
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- mRNA export from nucleus [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- positive regulation of mitotic cell cycle [IMP]
- regulation of translation [IDA]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.
As phospho-eIF4E (p-eIF4E), unlike total eIF4E (t-eIF4E) essential for normal cells, is specifically required by cancer cells, it is an attractive, yet unrealized, target for anti-tumor intervention. Here we identify a small molecule, homoharringtonine (HHT), that antagonizes p-eIF4E function and eradicates acute myeloid leukemia (AML) expressing high level of p-eIF4E in vitro and in vivo. HHT selectively reduces p-eIF4E levels ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ACVRL1 EIF4E | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID