STK11
Gene Ontology Biological Process
- activation of protein kinase activity [IDA]
- anoikis [IMP]
- cell cycle arrest [IDA, TAS]
- energy reserve metabolic process [TAS]
- establishment of cell polarity [ISS]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IDA]
- negative regulation of cell growth [ISS]
- negative regulation of cell proliferation [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of cell growth [ISS]
- regulation of fatty acid biosynthetic process [TAS]
- response to ionizing radiation [ISS]
- small molecule metabolic process [TAS]
- vasculature development [ISS]
Gene Ontology Molecular Function
BRSK1
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- axonogenesis [IMP]
- cellular response to DNA damage stimulus [ISO]
- centrosome duplication [IMP]
- establishment of cell polarity [IGI, IMP]
- neuron differentiation [IGI]
- neuron projection morphogenesis [IGI]
- neurotransmitter secretion [ISO]
- peptidyl-serine phosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to UV [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Structure and inhibition analysis of the mouse SAD-B C-terminal fragment.
The SAD (synapses of amphids defective) kinases, including SAD-A and SAD-B, play important roles in the regulation of neuronal development, cell cycle, and energy metabolism. Our recent study of mouse SAD-A identified a unique autoinhibitory sequence (AIS), which binds at the junction of the kinase domain (KD) and the ubiquitin-associated (UBA) domain and exerts autoregulation in cooperation with UBA. Here, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID