BAIT
MAPT
DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
microtubule-associated protein tau
GO Process (8)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PNPLA8
IPLA2(GAMMA), IPLA2-2, IPLA2G, iPLA2gamma, BM-043
patatin-like phospholipase domain containing 8
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- arachidonic acid metabolic process [IDA]
- arachidonic acid secretion [IDA]
- cell death [IDA]
- fatty acid metabolic process [IDA]
- glycerophospholipid biosynthetic process [TAS]
- linoleic acid metabolic process [IDA]
- phosphatidylcholine acyl-chain remodeling [TAS]
- phosphatidylcholine catabolic process [IDA]
- phosphatidylethanolamine acyl-chain remodeling [TAS]
- phosphatidylethanolamine catabolic process [IDA]
- phospholipid metabolic process [TAS]
- prostaglandin biosynthetic process [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Fibril treatment changes protein interactions of tau and ?-synuclein in human neurons.
In several neurodegenerative disorders, the neuronal proteins tau and ?-synuclein adopt aggregation-prone conformations capable of replicating within and between cells. To better understand how these conformational changes drive neuropathology, we compared the interactomes of tau and ?-synuclein in the presence or the absence of recombinant fibril seeds. Human embryonic stem cells with an inducible neurogenin-2 transgene were differentiated into glutamatergic ... [more]
J Biol Chem Mar. 01, 2023; 299(3);102888 [Pubmed: 36634849]
Throughput
- High Throughput
Additional Notes
- 0N4R Tau (P301L) 3wks post-seeding
- BioID2
Curated By
- BioGRID