MAPT
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CTNNA2
Gene Ontology Biological Process
- axonogenesis [ISS]
- brain morphogenesis [ISS]
- dendrite morphogenesis [ISS]
- muscle cell differentiation [TAS]
- positive regulation of muscle cell differentiation [TAS]
- prepulse inhibition [ISS]
- radial glia guided migration of Purkinje cell [ISS]
- regulation of synapse structural plasticity [ISS]
- single organismal cell-cell adhesion [ISS]
Gene Ontology Molecular Function
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Fibril treatment changes protein interactions of tau and ?-synuclein in human neurons.
In several neurodegenerative disorders, the neuronal proteins tau and ?-synuclein adopt aggregation-prone conformations capable of replicating within and between cells. To better understand how these conformational changes drive neuropathology, we compared the interactomes of tau and ?-synuclein in the presence or the absence of recombinant fibril seeds. Human embryonic stem cells with an inducible neurogenin-2 transgene were differentiated into glutamatergic ... [more]
Throughput
- High Throughput
Additional Notes
- 0N4R Tau (P301L) 3wks post-seeding
- BioID2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPT CTNNA2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3662109 |
Curated By
- BioGRID