MAPT
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CTNNA2
Gene Ontology Biological Process
- axonogenesis [ISS]
- brain morphogenesis [ISS]
- dendrite morphogenesis [ISS]
- muscle cell differentiation [TAS]
- positive regulation of muscle cell differentiation [TAS]
- prepulse inhibition [ISS]
- radial glia guided migration of Purkinje cell [ISS]
- regulation of synapse structural plasticity [ISS]
- single organismal cell-cell adhesion [ISS]
Gene Ontology Molecular Function
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. To dissect the underlying mechanisms, we combined an engineered ascorbic acid peroxidase (APEX) approach with quantitative affinity purification mass spectrometry (AP-MS) followed by proximity ligation assay (PLA) to characterize Tau interactomes modified by neuronal activity and mutations that cause frontotemporal dementia (FTD) in human induced pluripotent stem cell ... [more]
Throughput
- High Throughput
Additional Notes
- C-APEX tagged Tau
- ascorbic acid peroxidase (APEX)-tagged Tau approach followed by quantitative affinity purification mass spectrometry (AP-MS) followed by proximity ligation assay (PLA)
- interaction seen in KCl-treated neurons
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPT CTNNA2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3543363 |
Curated By
- BioGRID