GET2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPG1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex.
Mitophagy removes defective or superfluous mitochondria via selective autophagy. In yeast, the pro-mitophagic protein Atg32 localizes to the mitochondrial surface and interacts with the scaffold protein Atg11 to promote degradation of mitochondria. Although Atg32-Atg11 interactions are thought to be stabilized by Atg32 phosphorylation, how this posttranslational modification is regulated remains obscure. Here, we show that cells lacking the guided entry ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein activity (APO:0000022)
- phenotype: protein/peptide modification (APO:0000131)
Additional Notes
- genetic complex
- in get1/2 ppg1-double-null cells, Atg32 interacted with Atg11 at near WT levels
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GET2 PPG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.0843 | BioGRID | 325486 | |
GET2 PPG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.4123 | BioGRID | 900097 |
Curated By
- BioGRID