An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma.

Li XY, Wu JC, Liu P, Li ZJ, Wang Y, Chen BY, Hu CL, Fei MY, Yu PC, Jiang YL, Xu CH, Chang BH, Chen XC, Zong LJ, Zhang JY, Fang Y, Sun XJ, Xue K, Wang L, Chen SB, Jiang SY, Gui AL, Yang L, Gu JJ, Yu BH, Zhang QL, Wang L

The patients with relapsed and refractory diffuse large B-cell lymphoma (DLBCL) have poor prognosis, and a novel and effective therapeutic strategy for these patients is urgently needed. Although ubiquitin-specific protease 1 (USP1) plays a key role in cancer, the carcinogenic effect of USP1 in B-cell lymphoma remains elusive. Here we found that USP1 is highly expressed in DLBCL patients, and ... [more]

Leukemia Jan. 01, 2023; 37(1);164-177 [Pubmed: 36352191]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

USP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

cysteine-type endopeptidase activity [TAS]protein binding [IPI]ubiquitin thiolesterase activity [IDA]ubiquitin-specific protease activity [IDA, IMP]

Gene Ontology Cellular Component

AP3D1