BAIT

MOB4

2C4D, MOB1, MOB3, MOBKL3, PHOCN, PREI3, CGI-95
MOB family member 4, phocein
GO Process (0)
GO Function (1)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

SPTBN1

ELF, HEL102, SPTB2, betaSpII
spectrin, beta, non-erythrocytic 1
Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

Elkholi IE, Boulais J, Thibault MP, Phan HD, Robert A, Lai LB, Faubert D, Smith MJ, Gopalan V, Cote JF

Distinct functions mediated by members of the monopolar spindle-one-binder (MOB) family of proteins remain elusive beyond the evolutionarily conserved and well-established roles of MOB1 (MOB1A/B) in regulating tissue homeostasis within the Hippo pathway. Since MOB proteins are adaptors, understanding how they engage in protein-protein interactions, and help assemble complexes is essential to define the full scope of their biological functions. ... [more]

J Biol Chem Aug. 01, 2023; ();105123 [Pubmed: 37536630]

Throughput

  • High Throughput

Additional Notes

  • BFDR less than or equal to 0.01
  • BioID
  • Experiment performed in Hela cells

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MOB4 SPTBN1
Co-fractionation
Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

High-BioGRID
925764

Curated By

  • BioGRID