SGO1
Gene Ontology Biological Process
- centromere complex assembly [IMP]
- establishment of protein localization [IDA]
- establishment of protein localization to chromosome [IMP]
- kinetochore organization [IDA, IMP]
- maintenance of meiotic sister chromatid cohesion [IMP]
- meiotic sister chromatid segregation [IMP]
- meiotic sister chromatid separation [IMP]
- mitotic sister chromatid segregation [IGI, IMP]
- mitotic spindle assembly checkpoint [IGI, IMP]
- positive regulation of maintenance of meiotic sister chromatid cohesion [IGI, IMP]
- sister chromatid biorientation [IMP]
Gene Ontology Cellular Component
BUB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
During mitosis, sister chromatids attach to microtubules from opposite poles, called biorientation. Sister chromatid cohesion resists microtubule forces, generating tension, which provides the signal that biorientation has occurred. How tension silences the surveillance pathways that prevent cell cycle progression and correct erroneous kinetochore-microtubule attachments remains unclear. Here we show that SUMOylation dampens error correction to allow stable sister kinetochore biorientation ... [more]
Throughput
- High Throughput
Additional Notes
- Co-IP with Sgo1-4R or Sgo1
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
BUB1 SGO1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 522272 | |
SGO1 BUB1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 162507 |
Curated By
- BioGRID