BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADAM17
ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
ADAM metallopeptidase domain 17
GO Process (41)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- B cell differentiation [ISS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- Notch receptor processing [IDA]
- PMA-inducible membrane protein ectodomain proteolysis [IDA, IMP]
- T cell differentiation in thymus [ISS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- cell adhesion [IDA]
- cell adhesion mediated by integrin [IDA]
- cell motility [ISS]
- collagen catabolic process [TAS]
- epidermal growth factor receptor signaling pathway [IDA, TAS]
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- germinal center formation [ISS]
- membrane protein ectodomain proteolysis [IDA, IMP]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of interleukin-8 production [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- neutrophil mediated immunity [IC]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [ISS]
- positive regulation of chemokine production [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of epidermal growth factor-activated receptor activity [IDA, IMP]
- positive regulation of leukocyte chemotaxis [IC]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- proteolysis [IDA]
- regulation of mast cell apoptotic process [ISS]
- response to drug [ISS]
- response to high density lipoprotein particle [IDA]
- response to hypoxia [IDA]
- response to lipopolysaccharide [IDA]
- spleen development [ISS]
- wound healing, spreading of epidermal cells [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID