BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ENG
END, HHT1, ORW1, RP11-228B15.2
endoglin
GO Process (35)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- artery morphogenesis [ISS]
- cell chemotaxis [IMP]
- cell migration [IMP]
- cell motility [IMP]
- central nervous system vasculogenesis [IMP]
- chronological cell aging [IEP]
- detection of hypoxia [IDA]
- extracellular matrix disassembly [IMP]
- heart looping [ISS]
- intracellular signal transduction [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- negative regulation of protein autophosphorylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- patterning of blood vessels [ISS]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of systemic arterial blood pressure [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell adhesion [TAS]
- regulation of cell proliferation [TAS]
- regulation of phosphorylation [TAS]
- regulation of transcription, DNA-templated [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IDA]
- response to hypoxia [IDA]
- smooth muscle tissue development [ISS]
- transforming growth factor beta receptor signaling pathway [IDA]
- vasculogenesis [IMP]
- venous blood vessel morphogenesis [ISS]
- wound healing [IMP]
Gene Ontology Molecular Function- activin binding [TAS]
- galactose binding [IDA]
- glycosaminoglycan binding [IDA, ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor, cytoplasmic mediator activity [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane signaling receptor activity [NAS]
- type I transforming growth factor beta receptor binding [IPI, ISS]
- type II transforming growth factor beta receptor binding [IPI, ISS]
- activin binding [TAS]
- galactose binding [IDA]
- glycosaminoglycan binding [IDA, ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor, cytoplasmic mediator activity [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane signaling receptor activity [NAS]
- type I transforming growth factor beta receptor binding [IPI, ISS]
- type II transforming growth factor beta receptor binding [IPI, ISS]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID