BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP5
BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
low density lipoprotein receptor-related protein 5
GO Process (29)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- adipose tissue development [IMP]
- anterior/posterior pattern specification [IBA]
- bone marrow development [IMP]
- bone morphogenesis [IMP]
- bone remodeling [IBA]
- branching involved in mammary gland duct morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- cholesterol homeostasis [IMP]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic limb morphogenesis [IBA]
- embryonic retina morphogenesis in camera-type eye [IBA]
- gastrulation with mouth forming second [IBA]
- glucose catabolic process [IMP]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of protein serine/threonine kinase activity [IMP]
- osteoblast development [IBA]
- positive regulation of cell proliferation [IDA]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of mitosis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of blood pressure [IMP]
- regulation of canonical Wnt signaling pathway [IMP]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IBA]
- retina morphogenesis in camera-type eye [IMP]
- retinal blood vessel morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID