MESP1
Gene Ontology Biological Process
- cardiac atrium formation [IMP]
- cardiac cell fate determination [ISS]
- cardiac muscle cell differentiation [IMP]
- cardiac vascular smooth muscle cell differentiation [IMP]
- cardiac ventricle formation [IMP]
- cardioblast anterior-lateral migration [ISS]
- cardioblast migration to the midline involved in heart field formation [ISS]
- embryonic heart tube morphogenesis [ISS]
- endothelial cell differentiation [IMP]
- gastrulation [ISS]
- growth involved in heart morphogenesis [ISS]
- heart looping [ISS]
- lateral mesoderm development [ISS]
- negative regulation of endodermal cell fate specification [ISS]
- negative regulation of mesodermal cell fate specification [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- neurogenesis [IMP]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of hepatocyte differentiation [ISS]
- positive regulation of striated muscle cell differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [ISS]
- secondary heart field specification [ISS]
- sinoatrial node cell differentiation [IMP]
- sinus venosus morphogenesis [ISS]
Gene Ontology Molecular Function
SMC3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Essential role of MESP1-RING1A complex in cardiac differentiation.
Heart development is controlled by a complex transcriptional network composed of transcription factors and epigenetic regulators. Mutations in key developmental transcription factor MESP1 and chromatin factors, such as PRC1 and cohesin components, have been found in human congenital heart diseases (CHDs), although their functional mechanism during heart development remains elusive. Here, we find that MESP1 interacts with RING1A/RING1, the core ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID