WNT3
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [IMP]
- canonical Wnt signaling pathway involved in osteoblast differentiation [IMP]
- cell fate commitment [IBA]
- cell morphogenesis [IMP]
- cellular response to retinoic acid [ISS]
- limb bud formation [IMP]
- mammary gland epithelium development [IEP]
- neuron differentiation [IBA, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NEDD4L
Gene Ontology Biological Process
- cellular sodium ion homeostasis [NAS]
- excretion [NAS]
- gene expression [TAS]
- ion transmembrane transport [TAS]
- negative regulation of potassium ion transmembrane transport [IDA]
- negative regulation of potassium ion transmembrane transporter activity [IDA]
- negative regulation of protein localization to cell surface [IDA]
- negative regulation of sodium ion transmembrane transport [IDA]
- negative regulation of sodium ion transmembrane transporter activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of caveolin-mediated endocytosis [ISS]
- positive regulation of endocytosis [NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K48-linked ubiquitination [IDA]
- protein ubiquitination [IDA, NAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IDA]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane depolarization [IDA]
- regulation of membrane potential [IDA]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- regulation of protein catabolic process [NAS]
- response to metal ion [IDA]
- sodium ion transport [NAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- transmembrane transport [TAS]
- ventricular cardiac muscle cell action potential [ISS]
- viral life cycle [TAS]
- viral process [TAS]
- water homeostasis [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
(Pro)renin receptor promotes colorectal cancer progression through inhibiting the NEDD4L-mediated Wnt3 ubiquitination and modulating gut microbiota.
We previously found that (pro)renin receptor ((P)RR) augments Wnt3 protein without affecting Wnt3 gene transcription in colorectal cancer (CRC) cells, thus contributes to CRC initiation. The present study aims to investigate whether (P)RR further promotes CRC progression following oncogenesis and the related mechanisms. Notably, we deeply elaborate how (P)RR affects Wnt3 protein level and the key enzyme that mediates this ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID