THBS1
Gene Ontology Biological Process
- activation of MAPK activity [IMP]
- behavioral response to pain [ISS]
- blood coagulation [TAS]
- cell adhesion [NAS]
- cell cycle arrest [IDA]
- cell migration [IDA]
- cellular response to heat [NAS]
- chronic inflammatory response [IEP]
- engulfment of apoptotic cell [IDA]
- extracellular matrix organization [TAS]
- immune response [IEP]
- negative regulation of angiogenesis [IDA]
- negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cGMP-mediated signaling [IDA]
- negative regulation of cell-matrix adhesion [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dendritic cell antigen processing and presentation [IDA]
- negative regulation of endothelial cell chemotaxis [IDA]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of endothelial cell proliferation [IDA, IMP]
- negative regulation of extrinsic apoptotic signaling pathway [TAS]
- negative regulation of fibrinolysis [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA]
- negative regulation of focal adhesion assembly [TAS]
- negative regulation of interleukin-12 production [IDA]
- negative regulation of nitric oxide mediated signal transduction [IDA]
- negative regulation of plasma membrane long-chain fatty acid transport [IDA]
- negative regulation of plasminogen activation [IDA]
- peptide cross-linking [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood coagulation [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of chemotaxis [IDA]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of fibroblast migration [IDA]
- positive regulation of macrophage activation [IDA]
- positive regulation of macrophage chemotaxis [ISS]
- positive regulation of phosphorylation [IMP]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of transforming growth factor beta1 production [ISS]
- positive regulation of translation [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- regulation of cGMP metabolic process [IDA]
- response to calcium ion [IDA]
- response to drug [IEP]
- response to endoplasmic reticulum stress [ISS]
- response to glucose [IDA]
- response to hypoxia [NAS]
- response to magnesium ion [IDA]
- response to progesterone [TAS]
- sprouting angiogenesis [IMP]
Gene Ontology Molecular Function- calcium ion binding [NAS]
- collagen V binding [IDA]
- fibrinogen binding [IDA]
- fibroblast growth factor binding [IDA]
- fibronectin binding [IDA]
- glycoprotein binding [NAS]
- heparin binding [IDA]
- identical protein binding [NAS]
- integrin binding [IMP]
- laminin binding [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- proteoglycan binding [TAS]
- transforming growth factor beta binding [ISS, TAS]
- calcium ion binding [NAS]
- collagen V binding [IDA]
- fibrinogen binding [IDA]
- fibroblast growth factor binding [IDA]
- fibronectin binding [IDA]
- glycoprotein binding [NAS]
- heparin binding [IDA]
- identical protein binding [NAS]
- integrin binding [IMP]
- laminin binding [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- proteoglycan binding [TAS]
- transforming growth factor beta binding [ISS, TAS]
Gene Ontology Cellular Component
- cell surface [IDA]
- endoplasmic reticulum [ISS]
- external side of plasma membrane [IDA]
- extracellular matrix [IDA, ISS, TAS]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- fibrinogen complex [IDA]
- platelet alpha granule [IDA]
- platelet alpha granule lumen [TAS]
- sarcoplasmic reticulum [ISS]
- secretory granule [IDA]
MYH9
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- actin cytoskeleton reorganization [IMP]
- actin filament-based movement [IDA]
- actomyosin structure organization [IDA]
- angiogenesis [IDA]
- axon guidance [TAS]
- blood vessel endothelial cell migration [IMP]
- cytokinesis [IMP]
- integrin-mediated signaling pathway [NAS]
- leukocyte migration [NAS]
- membrane protein ectodomain proteolysis [IDA]
- monocyte differentiation [IEP]
- platelet aggregation [IMP]
- platelet formation [IMP]
- protein transport [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- actin cytoskeleton [IDA]
- actomyosin [IDA]
- actomyosin contractile ring [IDA]
- cell leading edge [IDA]
- cleavage furrow [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [IDA]
- integrin complex [IDA]
- membrane [IDA]
- myosin II complex [IDA]
- myosin II filament [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [IDA]
- ruffle [IDA]
- stress fiber [IDA]
- uropod [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis.
We determined the antitumor mechanism of apatinib in glioma using a patient-derived orthotopic xenograft (PDOX) glioma mouse model and glioblastoma (GBM) cell lines. The PDOX mouse model was established using tumor tissues from two glioma patients via single-cell injections. Sixteen mice were successfully modeled and randomly divided into two equal groups (n?=?8/group): apatinib and normal control. Survival analysis and in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| THBS1 MYH9 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| MYH9 THBS1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID