KIN4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPH3
Gene Ontology Biological Process
- double-strand break repair via homologous recombination [IGI]
- negative regulation of DNA damage checkpoint [IMP]
- negative regulation of glucose mediated signaling pathway [IMP]
- positive regulation of double-strand break repair via nonhomologous end joining [IMP]
- positive regulation of nitrogen compound metabolic process [IMP]
- protein dephosphorylation [IDA, IMP]
- signal transduction involved in meiotic recombination checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest.
Faithful chromosome segregation in budding yeast requires correct positioning of the mitotic spindle along the mother to daughter cell polarity axis. When the anaphase spindle is not correctly positioned, a surveillance mechanism, named as the spindle position checkpoint (SPOC), prevents the progression out of mitosis until correct spindle positioning is achieved. How SPOC works on a molecular level is not ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- SGA
- gene deletions that rescue the lethality of KIN4 overexpressed from the inducible GAL1 promoter
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PPH3 KIN4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2283 | BioGRID | 2094242 |
Curated By
- BioGRID