BAIT
DLG4
Dlgh4, PSD-95, PSD95, SAP90, SAP90A, RP23-172M21.9
discs, large homolog 4 (Drosophila)
GO Process (23)
GO Function (18)
GO Component (24)
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IBA, ISO]
- dendritic spine morphogenesis [IDA, ISO]
- establishment of protein localization [ISO]
- locomotory behavior [NAS]
- locomotory exploration behavior [IMP]
- negative regulation of receptor internalization [ISO]
- neuromuscular process controlling balance [IMP]
- nucleotide phosphorylation [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- protein complex assembly [ISO]
- protein localization to synapse [IDA, ISO]
- receptor localization to synapse [IBA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of grooming behavior [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI]
- regulation of neuronal synaptic plasticity [NAS]
- response to cocaine [NAS]
- signal transduction [IBA]
- social behavior [IMP]
- synaptic vesicle maturation [IDA, IGI]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA]
- cell junction [IDA]
- cerebellar mossy fiber [IDA]
- cortical cytoskeleton [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- ionotropic glutamate receptor complex [IDA]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [IDA]
- neuron spine [IDA]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [IDA]
- synaptic vesicle [IDA]
- voltage-gated potassium channel complex [ISO]
Mus musculus
PREY
DAB2IP
2310011D08Rik, AI480459, Aip1, mKIAA1743, RP23-4L24.1
disabled 2 interacting protein
GO Process (64)
GO Function (21)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IMP]
- activation of JUN kinase activity [ISO]
- activation of MAPKKK activity [ISO]
- cell motility involved in cerebral cortex radial glia guided migration [IMP]
- cellular protein catabolic process [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to interleukin-1 [IDA, ISO]
- cellular response to lipopolysaccharide [IDA, ISO]
- cellular response to tumor necrosis factor [IMP, ISO]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- layer formation in cerebral cortex [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of G0 to G1 transition [ISO]
- negative regulation of GTPase activity [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Ras GTPase activity [ISO]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of angiogenesis [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin catabolic process [ISO]
- negative regulation of endothelial cell migration [IMP, ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of epithelial cell migration [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of phosphatidylinositol 3-kinase activity [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein phosphorylation [IMP, ISO]
- negative regulation of protein serine/threonine kinase activity [IMP, ISO]
- negative regulation of toll-like receptor 4 signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- negative regulation of vascular endothelial growth factor signaling pathway [IDA]
- neuron projection morphogenesis [IMP]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [IMP, ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Ras GTPase activity [IBA, ISO]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of dendrite development [IMP]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein catabolic process [IMP]
- positive regulation of protein serine/threonine kinase activity [IMP, ISO]
- positive regulation of synapse maturation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of ARF GTPase activity [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of p38MAPK cascade [IMP]
- regulation of protein complex assembly [IMP, ISO]
- tube formation [IMP, ISO]
- vascular endothelial growth factor receptor-2 signaling pathway [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IBA, ISO]
- SH3 domain binding [ISO]
- Toll-like receptor 4 binding [IMP]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO]
- phosphatidylinositol-3-phosphate binding [ISO]
- phosphatidylinositol-4-phosphate binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IBA, ISO]
- SH3 domain binding [ISO]
- Toll-like receptor 4 binding [IMP]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO]
- phosphatidylinositol-3-phosphate binding [ISO]
- phosphatidylinositol-4-phosphate binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
Gene Ontology Cellular Component
- axon [IDA]
- cerebellar mossy fiber [IDA]
- climbing fiber [IDA]
- cytoplasm [IBA, IDA, ISO]
- endocytic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [IDA]
- neuronal cell body membrane [IDA]
- parallel fiber [IDA]
- plasma membrane [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.
Copy number variations (CNVs) are associated with psychiatric and neurodevelopmental disorders (NDDs), and most, including the recurrent 15q13.3 microdeletion disorder, have unknown disease mechanisms. We used a heterozygous 15q13.3 microdeletion mouse model and patient iPSC-derived neurons to reveal developmental defects in neuronal maturation and network activity. To identify the underlying molecular dysfunction, we developed a neuron-specific proximity-labeling proteomics (BioID2) pipeline, ... [more]
Mol Psychiatry Apr. 01, 2023; 28(4);1747-1769 [Pubmed: 36604605]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DLG4 DAB2IP | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.5362 | BioGRID | 3498544 |
Curated By
- BioGRID