DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IBA, ISO]
- dendritic spine morphogenesis [IDA, ISO]
- establishment of protein localization [ISO]
- locomotory behavior [NAS]
- locomotory exploration behavior [IMP]
- negative regulation of receptor internalization [ISO]
- neuromuscular process controlling balance [IMP]
- nucleotide phosphorylation [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- protein complex assembly [ISO]
- protein localization to synapse [IDA, ISO]
- receptor localization to synapse [IBA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of grooming behavior [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI]
- regulation of neuronal synaptic plasticity [NAS]
- response to cocaine [NAS]
- signal transduction [IBA]
- social behavior [IMP]
- synaptic vesicle maturation [IDA, IGI]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA]
- cell junction [IDA]
- cerebellar mossy fiber [IDA]
- cortical cytoskeleton [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- ionotropic glutamate receptor complex [IDA]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [IDA]
- neuron spine [IDA]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [IDA]
- synaptic vesicle [IDA]
- voltage-gated potassium channel complex [ISO]
GRIA2
Gene Ontology Biological Process
- establishment of protein localization [ISO]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- positive regulation of synaptic transmission [ISO]
- protein tetramerization [ISO]
- receptor internalization [ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic transmission, glutamatergic [ISO]
- synaptic transmission [IDA, ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- cell surface [ISO]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [ISO]
- perikaryon [ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, IDA]
- presynaptic membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [ISO]
- terminal bouton [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.
Copy number variations (CNVs) are associated with psychiatric and neurodevelopmental disorders (NDDs), and most, including the recurrent 15q13.3 microdeletion disorder, have unknown disease mechanisms. We used a heterozygous 15q13.3 microdeletion mouse model and patient iPSC-derived neurons to reveal developmental defects in neuronal maturation and network activity. To identify the underlying molecular dysfunction, we developed a neuron-specific proximity-labeling proteomics (BioID2) pipeline, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DLG4 GRIA2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| DLG4 GRIA2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low/High | - | BioGRID | 2333695 | |
| GRIA2 DLG4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIA2 DLG4 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.3105 | BioGRID | 3498795 | |
| DLG4 GRIA2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.5374 | BioGRID | 3498564 |
Curated By
- BioGRID