CLA4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDH1
Gene Ontology Biological Process
- activation of mitotic anaphase-promoting complex activity [IMP]
- negative regulation of spindle pole body separation [IGI, IMP]
- positive regulation of cyclin catabolic process [IDA]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of cell size [IMP]
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/CCdh1 complex.
H3K4 trimethylation (H3K4me3) is a conserved histone modification catalyzed by histone methyltransferase Set1, and its dysregulation is associated with pathologies. Here, we show that Set1 is intrinsically unstable and elucidate how its protein levels are controlled within cell cycle and during gene transcription. Specifically, Set1 contains a destruction box (D-box) that is recognized by E3 ligase APC/CCdh1 and degraded by ... [more]
Throughput
- Low Throughput
Ontology Terms
- protein/peptide modification (APO:0000131)
Additional Notes
- Loss of Cdh1 partly rescued the reduced H3K4me3 in cla4 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLA4 CDH1 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | High | -0.422 | BioGRID | 908743 | |
| CDH1 CLA4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.2 | BioGRID | 2358566 |
Curated By
- BioGRID